Los Rojiblancos’ eight-match winning streak came to an end at home on Monday after a last-gasp leveler from Facundo Ferreyra.
Atletico Madrid were denied a ninth consecutive La Liga victory after being held to a draw by Celta Vigo.
The 2-2 result at Wanda Metropolitano also prevented Atletico from restoring a 10-point lead at the top of the table.
Luis Suarez both leveled things up for his side and gave them the lead in a space of five minutes, breaking a Cristiano Ronaldo record in the process, after Santi Mina had opened the scoring.
The hosts looked set for another three points but Facundo Ferreyra got on the scoresheet at the 89th minute to ensure a share of the spoils.
Diego Simeone’s men still lead the title race with an eight-point gap over second-placed FC Barcelona with a game in hand.
“To be honest, I’m leaving here with lots of positives,” Simeone told in his post-match press conference, via Marca.
“The second halves from [Renan] Lodi, [Geoffrey] Kondogbia, [Lucas] Torreira… the performance of [Angel] Correa… They are very important things looking to the future.
“Neither team had many chances. We improved with the change of system in the second half, with Torreira and Kondogbia winning the ball back.
“The draw was fair. We didn’t deserve our goal in the first half and they didn’t deserve their equalizer.”